Table 1.

Staging of neurofibrillary tangles (NFT-related) pathology in Locus coeruleus (LC).

	Subcortical pretangles stages	a	P-Tau accumulation within the axon hillock of brainstem reticular neurons, mostly LC neurons.
		b	P-Tau accumulation extended further into LC cell bodies.
Pretangle Stages		c	Involvement of other reticular (or reticular-related) ascending nuclei (e.g., dorsal raphe nucleus, nuclei of the basal forebrain).
	Cortical pretangles stages	1a	Pre-tangle material in LC axons within the trans-entorhinal and entorhinal regions.
		1b	Pre-tangle inclusions within pyramidal cells of the trans-entorhinal region connected with NFT positive axons.