Table 2.
Effect of rosa damascenaon on body weight, water, food intake and other insulin resistance related parameters.
| parameter |
groups
|
P - value ¥ | |||
|---|---|---|---|---|---|
| HCG | Con | Pio | RDE | ||
| weight in 6 week (g) | 283±9 | 285±8 | 292±13 | 286±12 | 0.986 |
| weight in 8 week (g) | 285±9 | 307±8 | 294±16 | 275±9 | 0.042 |
| Weight gain (g) | 2±1.54* | 22.25±11.49# | 2.17±0.52# | -10.75±5.81* | <0.0001 |
| Water intake (mL) | 35±0.8* | 47±2# | 60±2# * | 56±1.2# | 0.151 |
| Food intake (g) | 21.6±0.7* | 13.4±0.4# | 13.5±0.3# | 12.8±0.1# | 0.978 |
| Insulin (pmol/L) | 50±4.8* | 137±34# | 40±2.7* | 42±2.7* | <0.0001 |
| Adiponectin (μg/mL) | 2.9±0.16 | 3.9±0.15 | 5.6±0.4# * | 5.6±0.17 * # | <0.0001 |
| Glucose (mg/dL) | 132±4* | 187±15# | 129±5.8* | 129±4.7* | 0.002 |
| HOMA.IR | 2.7±0.37* | 9.7±2.1# | 2.1±0.12* | 2.2±0.18* | <0.0001 |
| Cholesterol (mg/dL) | 71±12.1 | 59±3.2 | 63±4.2 | 55±3.18 | 0.986 |
| Triglyceride (mg/dL) | 85±13* | 217±18# | 200±51# | 75±9 * | <0.0001 |
HCG group was fed standard chow and the other three groups were fed a 60% fructose diet for 8 weeks. In Pio and RDE groups after the first 6 weeks, animals were treated by pioglitazone (10 mg/kg/day) or rosa damascenaextract (100 mg/kg/day) for 2 weeks. Biochemical parameters were measured by an auto analyzer. Hormones were analysed by ELISA method. HOMA-IR was calculated as mentioned above. All data are presented as Mean ± SEM. (n=8)
HCG: healthy control group, Con: control, Pio: pioglitazone, RDE: Rosa damascena extract