Table 1.
Physiological and biochemical markers of the studied animal groups: healthy control (sham), ovariectomized (OVX), hyperglycemic (STZ), and hyperglycemic-ovariectomized (STZ + OVX).
| Sham | OVX | STZ | STZ + OVX | |
|---|---|---|---|---|
| Body weight (g) at D 0 | 200.31 ± 5.92 | 206.57 ± 6.53 | 239.55 ± 4.42a | 249.16 ± 10.41a,b |
| Body weight (g) at D 60 | 218.49 ± 4.97 | 274.74 ± 9.98aa | 270.40 ± 10.37a | 300.49 ± 10.41aaa |
| E2 (pg/ml) | 16.50 ± 2.63 | <DL | 31.89 ± 7.71 | <DL |
| Glycemia (mg/dl) | 66.00 ± 15.20 | 87.33 ± 10.45 | 167.33 ± 7.54aa,b | 198.00 ± 21.65aaa,bb |
| Triglycerides (mg/dl) | 31.29 ± 2.29 | 34.29 ± 3.69 | 53.75 ± 5.90a | 57.71 ± 6.07a |
| Cholesterol (mg/dl) | 84.57 ± 3.77 | 97.00 ± 4.84 | 90.63 ± 4.77 | 98.67 ± 4.33 |
| HDL (mg/dl) | 39.33 ± 2.46 | 45.33 ± 2.91 | 38.2 ± 3.0 | 37.50 ± 5.86 |
| LDL (mg/dl) | 38.17 ± 3.23 | 49.14 ± 5.57 | 39.25 ± 4.30 | 43.71 ± 3.26 |
| Calcemia (mg/dl) | 10.47 ± 0.19 | 9.76 ± 0.15a | 10.26 ± 0.23 | 9.94 ± 0.29 |
| Urine 12 h (ml) | 3.9 ± 0.69 | 4.3 ± 0.72 | 7.2 ± 0.66aa,b | 7.6 ± 0.75aa,b |
| Calciuria (mg/dl) | 31.48 ± 4.47 | 65.14 ± 3.29a,c,d | 34.68 ± 4.77 | 37.59 ± 6.13 |
| Ca2+ clearance (ml/min) | 0.016 ± 0.002 | 0.040 ± 0.002a | 0.034 ± 0.005 | 0.040 ± 0.007a |
| CTX (ng/ml) | 9.38 ± 0.64 | 15.45 ± 1.86a,c | 9.43 ± 0.91 | 15.88 ± 1.43a,c |
| PINP (ng/ml) | 14.66 ± 1.26 | 21.33 ± 0.61a | 18.58 ± 1.58 | 25.01 ± 2.15aa |
| PINP/CTX | 1.57 ± 0.06 | 1.39 ± 0.11 | 1.97 ± 0.0.09bb | 1.66 ± 0.13 |
Average results ± standard error; n = 7 per group; ap < 0.05, aap < 0.01, aaap < 0.001 compared to sham; bp < 0.05, bbp < 0.01 compared to OVX; cp < 0.01, dp < 0.05 compared to STZ + OVX; DL: detection limit = 11.8 pg/ml.