Table 2.
The effects of AMPSc on oxidative statues in serum or hypothalamus in AD mice.
| CTRL | CTRL + AMPSc (mg/kg) | AlCl3 + D-gal | AlCl3 + D-gal + AMPSc (mg/kg) | |||
|---|---|---|---|---|---|---|
| 100 | 25 | 100 | ||||
| Serum | SOD (U/mL) | 98.6 ± 7.4 | 117.0 ± 5.7# | 75.9 ± 3.9# | 110.3 ± 5.3∗∗ | 111.5 ± 9.0∗∗ |
| GSH-Px (U/mL) | 249.8 ± 13.1 | 251.3 ± 5.7 | 213.4 ± 10.5## | 254.4 ± 9.0∗∗ | 290.9 ± 16.0∗∗∗ | |
| Hypothalamus | SOD (U/mgprot) | 44.4 ± 2.1 | 55.9 ± 4.6# | 30.1 ± 2.6## | 47.0 ± 4.8∗∗ | 66.1 ± 6.4∗∗∗ |
| GSH-Px (U/mL) | 326.1 ± 13.9 | 385.0 ± 27.2# | 282.3 ± 16.4# | 405.7 ± 31.1∗∗ | 501.4 ± 15.2∗∗∗ | |
| ROS (FI/mgprot) | 23087.4 ± 1905.5 | 15564.8 ± 3030.9# | 34418.8 ± 3986.2# | 14104.1 ± 1260.5∗∗ | 17877.6 ± 2713.4∗∗∗ | |
Treatment with AMPSc and the levels of SOD, GSH-Px, and ROS in serum and/or hypothalamus were detected via ELISA method. Data are expressed as mean ± S.E.M. (n = 10). #P < 0.05 and ##P < 0.01 versus normal mice (CTRL); ∗∗P < 0.01 and ∗∗∗P < 0.001 versus AD mice.