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Effects of SIRT1 overexpression on NMDA-induced the amount of LDH release the in SH-SY5Y cell line. WT-SIRT1 overexpression reduced NMDA-induced LDH release (P < 0.05), and DN-SIRT1 overexpression did not protect against NMDA-mediated LDH release (P > 0.05). Each value represents the mean ± S.E.M. of six independent experiments. ∗P < 0.05 versus the control group, #P < 0.05 versus the NMDA group, &P < 0.05 versus the WT-SIRT1 + NMDA group.
