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Effects of RSV on NMDA-induced decrease of SIRT1 deacetylase activity in primary neurons. RSV (25 μM) significantly ameliorated SIRT1 activity reduced by NMDA (P < 0.05), and Sirtinol (10 μM) abolished the effect of RSV (P < 0.05). MK: MK-801. Each value represents the mean ± S.E.M. of six independent experiments. ∗P < 0.05 versus the control group, #P < 0.05 versus the NMDA group, &P < 0.05 versus the RSV + NMDA group.
