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Effects of SIRT1 overexpression on the deacetylase activity in NMDA-induced excitotoxicity of SH-SY5Y cell. WT-SIRT1 overexpression significantly reversed the deacetylase activity decreased by NMDA (P < 0.05), and DN-SIRT1 overexpression had no effect (P > 0.05). Each value represents the mean ± S.E.M. of six independent experiments. ∗P < 0.05 versus the control group. #P < 0.05 versus the vector + NMDA group, &P < 0.05 versus the WT-SIRT1 + NMDA group.
