Skip to main content
. 2017 Sep 1;2017:2823454. doi: 10.1155/2017/2823454

Figure 8.

Figure 8

Effects of SIRT1 overexpression on p53 acetylation in NMDA-induced excitotoxicity of SH-SY5Y cell. WT-SIRT1 overexpression partially inhibited NMDA-stimulated p53 acetylation (P < 0.05), and DN-SIRT1 overexpression had no effect (P > 0.05). (a) Western blot probed with antibodies against p53 and Ace-p53. (b) Quantitative representations of Ace-p53 by bar graph. Each value represents the mean ± S.E.M. of three independent experiments. ∗P < 0.05 versus the control group, #P < 0.05 versus the NMDA group.