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Effects of SIRT1 overexpression on cell viability reduced by NMDA in the SH-SY5Y cell line. WT-SIRT1 overexpression reversed NMDA-induced decrease in cell viability (P < 0.05), and DN-SIRT1 overexpression did not affect cell viability in the NMDA group (P > 0.05). Each value represents the mean ± S.E.M. of six independent experiments. ∗P < 0.05 versus the control group, #P < 0.05 versus the NMDA group, &P < 0.05 versus the WT-SIRT1 + NMDA group.
