Table 1.
Mitochondrial respiration and sirtuin 3 (SIRT3) expression/activity in patients with movement disorders and in controls. Results are presented as mean ± standard deviation (ROUTINE, ROX) and median (interquartile range for LEAK, ETS, and SIRT3). All outcomes of mitochondrial respiration are measured in pmol O2/s∗106 cells. SIRT3 protein expression is represented as μg/mg protein. SIRT3 activity is represented as U/μg protein.
| Controls n = 10 |
Patients with movement disorders n = 57 |
P | |
|---|---|---|---|
| ROUTINE (pmol O2/s∗106 cells) |
19.3 ± 4.4 | 15.3 ± 4.5 | 0.0237 |
| LEAK (pmol O2/s∗106 cells) |
6.02 5.37–6.78 |
4.2
2.98–5.68 |
0.033 |
| ETS (pmol O2/s∗106 cells) |
13.34 11.22–17.39 | 12.21 9.84–15.79 | 0.4168 |
| ROX (pmol O2/s∗106 cells) | 5.7 ± 1.6 | 4.2 ± 2.0 | 0.0486 |
| SIRT3 expression (μg/mg protein) |
63.9 20.5–115.4 | 35.4 23.2–57.9 | 0.4309 |
| SIRT3 activity (U/μg protein) |
181.17 60.9–344.6 |
71.40
38.7–132.9 |
0.0178 |