Table 3.
Comparison of mitochondrial respiration and sirtuin 3 (SIRT3) expression/activity in a subgroup of patients with movement disorders with substantia nigra hyperechogenicity and in controls. Results are presented as mean ± standard deviation (ROUTINE and ROX) and median (interquartile range for LEAK, ETS, and SIRT3). All outcomes of mitochondrial respiration are measured in pmol O2/s∗106 cells. SIRT3 protein expression is represented as μg/mg protein. SIRT3 activity is represented as U/μg protein.
| Controls (C) n = 10 |
Substantia nigra hyperechogenicity present (SNH+) (59%) |
Substantia nigra hyperechogenicity absent (SNH-) (41%) |
P (SNH+) versus C | P (SNH−) versus C | P (SNH+) versus (SNH−) | |
|---|---|---|---|---|---|---|
| ROUTINE (pmol O2/s∗106 cells) |
19.3 ± 4.4 | 14.1 ± 3.6 | 15.9 ± 4.9 | 0.007 | 0.1332 | 0.3768 |
| LEAK (pmol O2/s∗106 cells) |
6.02 5.37–6.78 |
3.4
2.1–5.2 |
4.4 3.6–5.5 |
0.0203 | 0.0822 | 0.6603 |
| ETS (pmol O2/s∗106 cells) |
13.34 11.22–17.39 |
12.1 9.9–15.2 |
12.2 9.3–14.3 |
0.1947 | 0.3465 | 0.9167 |
| ROX (pmol O2/s∗106 cells) |
5.7 ± 1.6 | 4.1 ± 2.0 | 4.1 ± 2.5 | 0.0801 | 0.1337 | 0.9484 |
| SIRT3 expression (μg/mg protein) |
63.9 20.5–115.4 |
35.5 24.0–47.8 |
42.7 19.4–60.1 |
0.9606 | 0.6666 | 0.9606 |
| SIRT3 activity (U/μg protein) |
181.17 60.9–344.6 |
90.1 37.3–141.2 |
66.6
34.7–137.3 |
0.6570 | 0.0364 | 0.6570 |