Table 4.
miRNA associated with neurogenesis modified after different stimulus.
| miRNA | Expression level | Cellular process | Molecular target | Reference |
|---|---|---|---|---|
| miR-181a | Upregulated by morphine | Promote astrocyte-preferential differentiation of NSPCs | Prox1/Notch2 | [159] |
| miR-23b | Upregulated by morphine | Adult neurogenesis | Morphine receptor expression (MOR1) | [160] |
| miR-190 | Downregulated by fentanyl | Adult neurogenesis | NeuroD | [161] |
| miR-143 | Upregulation by IGF-1 | Promotes proliferation, neural differentiation, and cell survival | PDGFRA, PRKCE, MAPK7, DSSP, DMP-1, KRAS, and BCL-2 | [162] |
| miR-181c | Upregulation by IGF1/LIF | Enhanced self-renewal of NSPCs | PTPN11, PTPN22, PTEN, Dusp6, PBX3, ZEB2, and IRF8 | [162] |