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. Author manuscript; available in PMC: 2018 Sep 15.
Published in final edited form as: J Mol Biol. 2017 Aug 14;429(19):2954–2973. doi: 10.1016/j.jmb.2017.08.003

Figure 6. Comparison of the activities of ROR1-targeting XBR1-402 CAR-Ts with short and long spacer.

Figure 6

(A) Membrane distal epitope location of XBR1-402 on ROR1. Using XBR1-402-derived CARs containing CD3ζ and 4-1BB signaling domains and either a short (12 aa) or a long IgG4-derived spacer (229 aa), proliferation (B) and cytotoxicity studies (C) were carried out as described for Figure 5.