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. Author manuscript; available in PMC: 2018 Sep 15.
Published in final edited form as: J Mol Biol. 2017 Aug 15;429(19):2873–2894. doi: 10.1016/j.jmb.2017.08.004

Fig. 7. Two types of R-loops and a model of chromosomal fragmentation in the RNase H-deficient mutants.

Fig. 7

Blue lines, DNA strands; orange lines, RNA strands; arrowheads, direction of strand extension; smaller navy font, DNA metabolism processes; bigger black font, various R-lesions. A. Two types of R-loops in relation to replication. B. The model of chromosomal fragmentation in the absence of RNase H activities. Mis-maturation — incomplete maturation of Okazaki fragments. The last step with pink arrow — any cellular ssRNA endoribonuclease.