Figure 2. Deficiency of Ccr2, Cx3cr1 or both had no effects on weight gain or body composition in HFD-fed male mice.
Male WT, Ccr2−/−, Cx3cr1−/− and Cx3cr1−/−Ccr2−/− mice were fed with 45% HFD (45% calories from fat) starting at 12-weeks of age. A: Weight gain over 25 weeks of feeding with 45% HFD was identical between groups (n=12 WT, 12 Ccr2−/−, 9 Cx3cr1−/−, 16 Cx3cr1−/−Ccr2−/−). B: After 25 weeks of HFD feeding, body fat and lean mass were measured by NMR after a 5-hour fast and there were no differences between groups (n=9 WT, 10 Ccr2−/−, 8 Cx3cr1−/−, 17 Cx3cr1−/−Ccr2−/−). Data are mean±SEM. N.S., not significant.