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. 2017 Sep 20;11:66. doi: 10.3389/fncir.2017.00066

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Copyright © 2017 Lü, Yang, Li, Wang, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peripheral effects of α1, α2 and β adrenoceptor antagonists on development of the empathic mechanical pain hypersensitivity in the CO rats. (A) showing changes in PWMT in the CO rats with pre-administration of prazosin (n = 12), yohimbine (n = 7) and propranolol (n = 7), respectively, into one hand paw (drug side). (B) showing effect of prazosin on the baseline PWMT in the CC rats (n = 9). Contrl., contralateral side to the drug injection; PWMT, paw withdraw mechanical threshold. *P < 0.05, **P < 0.01 vs. pre-treatment. Data are expressed as mean ± SEM.