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. 2017 Sep 20;8:1162. doi: 10.3389/fimmu.2017.01162

Figure 3.

Figure 3

CD4 T-cell dynamics in children on early antiretroviral therapy (ART) and on continuous ART restarted after treatment interruption. (A) Individual CD4 z-score trajectories for children on early ART for 96 weeks (ART-96W) and 40 weeks (ART-40W). (B) Individual CD4 z-score trajectories on continuous ART restarted after treatment interruption. (C) Means and SEs in the mean (±SEM) of combined ART-96W and ART-40W CD4 z-scores for each sampling time on early treatment. The continuous straight line indicates the population-average model fit for the ART-96W and 40 W samples, showing stability of the z-scores over time. The z-scores in these early-treated children are significantly lower than the mean (±SEM) of the HIV-uninfected Child Wellness Clinic (CWC) cohort. (D) Means and SEM of CD4 z-scores for each sampling time after ART restart, with the population-average model fit. The discrepancy between the beginning of the curve and the first point is likely to be due to redistribution of memory T-cells in response to ART restart and viral suppression.