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. 2017 Sep 20;8:485. doi: 10.3389/fneur.2017.00485

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Copyright © 2017 de Assis, Saute, Longoni, Haas, Torrez, Brochier, Souza, Furtado, Gheno, Russo, Monte, Castilhos, Schumacher-Schuh, D’Avila, Donis, de Mello Rieder, Souza, Camey, Leotti, Jardim and Portela.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Redox parameters in healthy controls, symptomatic, and presymptomatic SCA3/MJD individuals. (A) ROS levels, (B) SOD activity, (C) GSH-Px activity and (D) Correlation between GSH-Px and NESSCA. Values are presented as the means, and error bars represent standard error; *p < 0.05 and ***p < 0.001. GSH-Px, glutathione peroxidase; NESSCA, Neurological Examination Score for Spinocerebellar Ataxias; ROS, reactive oxygen species; SCA3/MJD, spinocerebellar ataxia type 3/Machado–Joseph disease; SOD, superoxide dismutase.