Table 1.
Characteristics of study participants of the three discovery cohorts in the meta-analysis of genome-wide association studies of severity of coronary artery disease using the Gensini score.
| Discovery |
Replication |
|||||
|---|---|---|---|---|---|---|
| AtheroGene n = 1,168 | LIFE Heart n = 1,603 | LURIC n = 1,899 | Vivit n = 1,235 | stenoCardia n = 490 | INTERCATH n = 546 | |
| Age, years, mean ± SD | 63 ± 9.8 | 63.4 ± 11.3 | 62.3 ± 10.8 | 64.2 ± 10.5 | 64 ± 11 | 69.7 ± 10.6 |
| Women, % | 257 (22) | 427 (26.6) | 603 (31.8) | 343 (27.8) | 144 (29.4) | 151 (27.8) |
| Gensini score, median (25th–75th percentile) | 38 (18–65.5) | 24 (6–48) | 27 (5–53.5) | 15 (1–42) | 23 (9–48) | 16 (6.5–38) |
| Hypertension, % | 838 (71.7) | 1067 (66.6) | 1364 (71.8) | 1012 (82.0) | 383 (78.2) | 429 (81.2) |
| Diabetes mellitus, N (%) | 248 (21.2) | 533 (33.3) | 746 (39.3) | 366 (29.7) | 83 (16.9) | 151 (28.3) |
| Current cigarette smoker, N (%) | 366 (31.3) | 421 (26.3) | 455 (24.0) | 229 (18.6) | 147 (30.1) | 84 (16.5) |
| Former cigarette smoker, N (%) | 363 (31.1) | 624 (38.9) | 723 (38.1) | 535 (43.4) | 140 (29.1) | 249 (48.9) |
| Total cholesterol, mg/dL, mean ± SD | 215.0 ± 48.5 | 207.0 ± 47.5 | 193.4 ± 38.9 | 204.7 ± 46.9 | 209.2 ± 47.0 | 167.7 ± 47.7 |
| HDL cholesterol, mg/dL, mean ± SD | 48.8 ± 14.4 | 47.5 ± 13.6 | 39.0 ± 10.9 | 52.6 ± 15.5 | 48.5 ± 13.6 | 47.8 ± 21.2 |
| LDL cholesterol, mg/dL, mean ± SD | 138.8 ± 43 | 129 ± 42 | 116.6 ± 34.4 | 128.03 ± 39.12 | 130.2 ± 42.2 | 93.6 ± 38.6 |
| Triglycerides, mg/dL, mean ± SD | 165.37 ± 114.6 | 173 ± 108 | 170.9 ± 121.6 | 151.6 ± 99.8 | 162.2 ± 123.9 | 153.8 ± 195.7 |
| Body mass index, kg/m2, mean ± SD | 27.5 ± 3.7 | 29.5 ± 4.8 | 27.5 ± 4.1 | 27.4 ± 4.2 | 27.9 ± 4.2 | 27.2 ± 5.2 |
| History of MI, N (%) | 280 (24) | 400 (25) | 710 (37.4) | 363 (29.3) | 95 (19.8) | 123 (23.5) |