Table 1.
Body regions/conditions in which NAA concentrations and/or Nat8l/Aspa expression have been determined in physiological and pathological conditions outside the CNS.
| Tissue/condition | NAA concentration (method used for detection) | Nat8l | Aspa | Literature |
|---|---|---|---|---|
| Brown adipose tissue | mRNA, protein | mRNA, protein | Pessentheiner et al. (10), Prokesch et al. (11) | |
| Brown adipocytes | Up to 20 nmol/mg protein (HPLC/HRMS; LC-MS/MS) | mRNA, protein | mRNA, protein, activity | Pessentheiner et al. (10), Prokesch et al. (11) |
| White adipose tissue, human white adipocytes | mRNA | mRNA | Pessentheiner et al. (10), Prokesch et al. (11) | |
| Non-small cell lung cancer (NSCLC) | Blood (up to 200 nM) Tumor (5–15 µM) Cells (relative) (HPLC, GC-MS) |
Tumor (mRNA) Cells (protein) |
Lou et al. (12) | |
| High-grade serious ovarian cancer (HGSOC) | Ovarian cancer (~60 μM) (NMR) | mRNA, Protein | mRNA | Zand et al. (13) |
| Inflammatory breast cancer (IBC) | Cells (relative) (LC-MS) | mRNA | Wynn et al. (14) | |
| Duodenum of obese/diabetic mouse model | Protein, activity | Surendran et al. (15) | ||
| Adipose tissues of obese/diabetic mouse model | mRNA | mRNA | Pessentheiner et al. (10) |