Figure 4.

UCP1 basal promoter elements alignment for select mammalian species with putative protein binding motifs indicated. Highlighted sites indicate shared nucleotides to the species in which the motif was first described (mouse or rat) and the typical TATA box (5′-TATAAAA-3′) sequence (Xu et al., 1991). The consensus sequence represents the simple majority based on species for which the UCP1 gene is intact. Species with documented UCP1 pseudogenes (Gaudry et al., 2017) are denoted in red font and were not included in the consensus calculations.