Figure 1. A: Podoplanin (PDPN) immunohistochemistry in showing cytoplasmic staining of tumour cells at low magnification (×40) and at high magnification (inset; ×100), score 2+. B-D: PDPN mRNA signal was identified in tumour cells as multiple small brown dots as indicated by red arrow: score 1, with 0-1 dots/cell, (B); score 2, 4-10 dots/cell (C); score 4, >10 dots/cell and more than 10% positive cells with dot clusters (D).