Figure 1.

Hypoxia (10% oxygen level) could significantly increase migration of vascular endothelial cells. (A) Micrographs of wound healing experiments with vascular endothelial cells cultured in normoxia or hypoxia (10% oxygen level). (B) Hypoxia (10% oxygen level) could significantly increase the migration of vascular endothelial cells compared with cells cultured in normoxia. (C) Micrographs of wound healing experiments with vascular endothelial cells cultured in normoxia or hypoxia (8% oxygen level). (D) Hypoxia (8% oxygen level) exerted no effect on the migration of vascular endothelial cells. A total of 8–12 visual fields were chosen at random in one culture dish. The value of each wound area was converted to a standard value shown as one data point through division by a fixed value which renders the average value of the control group to be 100. The data are described as mean ± SEM. Bar = 200 μm. ^*P < 0.05.