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. 2017 Aug 1;7(8):e1188. doi: 10.1038/tp.2017.159

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Enrichment of prenatally expressed genes at multiple P-value thresholds. After LD-pruning, each single-nucleotide polymorphism (SNP) was assigned to the nearest gene within 2 megabases. Elevated prenatal expression was defined as a fetal/postnatal log2 fold-change threshold of 0.5. Analyses were performed using both the microarray-based ‘BrainCloud’ dorsolateral prefrontal cortex (DLPFC) transcriptome³¹ and the RNA sequencing-based Brainspan transcriptome of 15 different brain regions.³² Left panels show −log₁₀ P-values. Orange line represents the threshold for statistical significance. Right panels show percentage of genes with elevated prenatal expression. (a) intracranial volume (ICV). (b) white matter (WM). (c) gray matter (GM). (d) CSF.