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. 2017 Aug 1;7(8):e1188. doi: 10.1038/tp.2017.159

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Sign tests suggest minimal overlap between common variants impacting brain volumes in neonates, adolescents and adults. (a) Left panel shows –log₁₀ P-values for two-sided exact binomial tests comparing single-nucleotide polymorphisms (SNPs) impacting intracranial volume (ICV) and ICV-adjusted white matter (WM) and gray matter (GM) in neonates to the same SNPs in adolescents (PNC). Right panel shows percent overlap. Tests for ICV-adjusted WM are significant (P=0.02, 0.04 and 0.01) at the thresholds of P<0.001, P<0.01, and P<0.1, respectively. (b) Left panel shows –log₁₀P-values for two-sided exact binomial tests comparing SNPs impacting ICV in neonates to the same SNPs in adults (ENIGMA2). Right panel shows percent overlap. Test is significant at the threshold of P<0.1 (P=0.02). (c) Left panel shows –log₁₀ P-values for two-sided exact binomial tests comparing SNPs impacting ICV in adolescents (PNC) to the same SNPs in adults (ENIGMA2). Right panel shows percent overlap. Test is significant at the threshold of P<0.1 (P=0.001). * indicates significance.