Table 2. Amygdalar and hippocampal volumes: descriptives.
|
FEP |
||||||
|---|---|---|---|---|---|---|
|
Non-ePNS |
||||||
| Time point | Structure | Side | (1) ePNS | (2) sPNS | (3) Non-PNS | (4) Controls |
| Baseline (scan 1) | Amygdala | L | 1386.9 (22.6) | 1358.7 (18.6) | 1362.2 (15.4) | 1377.4 (15.5) |
| R | 1404.5 (22.0) | 1370.5 (18.1) | 1381.7 (15.0) | 1384.6 (15.0) | ||
| Hippocampus | L | 2488.3 (52.0) | 2452.1 (42.8) | 2517.4 (35.4) | 2536.1 (35.5) | |
| R | 2471.0 (52.7) | 2421.4 (43.4) | 2433.9 (35.9) | 2490.9 (36.0) | ||
| FUP1 (scan 2) | Amygdala | L | 1384.6 (23.4) | 1359.9 (19.0) | 1365.7 (15.8) | 1367.3 (15.8) |
| R | 1398.5 (22.9) | 1362.9 (18.6) | 1383.7 (15.4) | 1395.8 (15.5) | ||
| Hippocampus | L | 2486.5 (52.2) | 2485.6 (42.4) | 2530.3 (35.1) | 2530.8 (35.2) | |
| R | 2446.7 (54.5) | 2453.8 (44.3) | 2443.2 (36.7) | 2492.1 (36.8) | ||
| FUP2 (scan 3) | Amygdala | L | 1371.1 (25.7) | 1363.7 (27.5) | 1366.1 (20.7) | 1395.2 (21.7) |
| R | 1394.2 (24.3) | 1379.2 (26.0) | 1390.4 (19.5) | 1403.9 (20.5) | ||
| Hippocampus | L | 2499.5 (52.6) | 2457.5 (56.3) | 2557.4 (42.3) | 2567.8 (44.3) | |
| R | 2448.7 (53.2) | 2453.7 (56.9) | 2483.4 (42.7) | 2499.3 (44.8) | ||
Abbreviations: ePNS, early persistent negative symptom; FEP, first-episode of psychosis; FUP, follow-up; L, left; R, right; sPNS, persistent negative symptoms due to secondary factors.
Mean hippocampal and amygdalar volumes are adjusted for total brain volume, age, sex and handedness, with s.e. in brackets. There were no differences in volumes between groups when looking at the data cross-sectionally.