Table 3. Clinical information of carriers of the RTN4R-R292H mutation.
| Subject 1 | Subject 2 | Subject 3 | Subject 4 | Subject 5 | Subject 6 | |
|---|---|---|---|---|---|---|
| Diagnosis | Schizophrenia | Schizophrenia | Schizophrenia | Schizophrenia | Schizophrenia | Schizophrenia |
| Age (at participation), years | 55 | 59 | 68 | 28 | 40 | 20 |
| Sex | Male | Female | Female | Male | Male | Male |
| Family history (mental illness) | Schizophrenia (cousin), suicide attempt (mother) | Schizophrenia, mental retardation (daughter) | — | Schizophrenia (cousin) | depression (mother) | — |
| Developmental anomaly | — | — | — | Mild mental retardation | — | — |
| Education (years) | High school (12) | Junior high school (9) | High school (12) | Junior high school (9) | University (14) | University (14) |
| Occupation | Public servant | Restaurant staff for 10 years | Clerical staff | Part-time job at restaurant | Welfare service worker | Part-time job |
| Marriage | − | + | + | − | − | − |
| Age at onset | 22 | 42 | 22 | 24 | 20 | 19 |
| Symptoms at onset | Auditory hallucinations, persecutory delusion | Delusion of possession, and loose association | Persecutory delusion, descent delusion, catatonia | Auditory hallucinations, persecutory delusion | Auditory hallucinations, delusion of observation | Auditory hallucination delusion of reference |
| Clinical course after onset | Repeated hospitalization over 24 years | Repeated hospitalization | Repeated hospitalization | Hospitalized for a year then followed up as an outpatient | Repeated hospitalization | Repeated hospitalization |
| Cognitive test after onset | NA | NA | NA | WAIS: VIQ57, PIQ48, TIQ49 | NA | NA |
| Physical illness | Chronic bronchitis, lung cancer | — | Diabetes mellitus | Hiccups and appendicitis | Asthma, urethral stone | — |
Abbreviations: −, absent; +, present; IQ, intelligence quotient; NA, not available; PIQ, performance IQ; TIQ, total IQ; VIQ, verbal IQ; WAIS, Wechsler Adult Intelligence Scale.