. 2017 Aug 15;7(8):e1204. doi: 10.1038/tp.2017.180

Table 1. Results of all voxel-wise statistical analyses.

Analysis	Condition	Region name	Cluster size	Max T/F	X	Y	Z	Passed SnPM
Main effect	Worry	Bilateral lingual/cuneus/MOG/fusiform/IOG	1717	T₍₃₉₎=5.7	20	−90	−22	Yes
		Bilateral thalamus/caudate/ACC	2822	T₍₃₉₎=7.2	−14	−10	12	Yes
		Left SMA (BA8)/mPFC/dACC (BA32)	1503	T₍₃₉₎=5.3	−8	12	56	Yes
	Reappraisal	Bilateral lingual/calcarine/MOG	3619	T₍₃₁₎=5	−18	−78	−8	Yes
		Bilateral thalamus	2210	T₍₃₁₎=6	6	−26	12	Yes
		Bilateral MeFG/olfactory/SFG (orbital)	521	T₍₃₁₎=−4	8	18	−18	No

Group-by-block interaction	Worrya	Left posterior insula	332	F_(1,152)=15	−34	−16	22	No
		Right anterior hippocampus	494	F_(1,152)=16.2	34	−20	−20	No
	Reappraisal	Not significant

Block effect	Worry	Bilateral thalamus/parahippocampus/hippocampus	4801	F_(4,156)=8.7	12	−30	6	No
	Reappraisal	Not significant

Group differences (GAD−HC)	Worry	Left MTG/STG	520	T₍₃₈₎=3.8	−64	−18	−4	No
		Right MFG/SFG	483	T₍₃₈₎=5.2	38	62	−2	No
		Left PoCG/PreCG/MFG/IPL	2005	T₍₃₈₎=4.8	−36	−26	64	Yes
		Right SPL/precuneus/PoCG/IPL/angular/SOG	3575	T₍₃₈₎=5.0	−16	−84	50	Yes
		Right SFG/MeFG	462	T₍₃₈₎=4.2	6	38	62	No
	Reappraisal	Right putamen/insula	499	T₍₃₀₎=−3.7	34	4	10	No
		Left MTG/STG	696	T₍₃₀₎=4.4	−64	−34	4	No
		Left insula/IFG (oper)	1928	T₍₃₀₎=−6.3	−30	0	22	Yes
		Right MCC/SFG/SMA	2254	T₍₃₀₎=−7.5	28	16	68	Yes
		Right PreCG/PoCG	541	T₍₃₀₎=4.5	12	−32	76	No

Group differences adjusted for HDRS	Worry	Not significant

	Reappraisal	Not significant
Group differences adjusted for D–KEFS set-switching and inhibition	Worry	Left PoCG/PreCG/IPL	626	T₍₃₆₎=3.9	−50	−36	60	No
	Reappraisal	Left lentiform nucleus/putamen/pallidum	443	T₍₃₆₎=−5.1	−22	−12	6	Yes
		Right SFG/MCC/SMA	992	T₍₂₈₎=−7.1	28	16	68	Yes
		Left MFG/PreCG	472	T₍₂₈₎=−5.1	−30	18	64	No

Association between CBF and PSWQ	Worry	Right parahippocampus	482	T₍₃₈₎=4	8	10	−26	Yes
		Right MFG/SFG/IFG	1650	T₍₃₈₎=5.3	38	62	−2	Yes
		Left MTG/STG	496	T₍₃₈₎=4	−68	−20	−4	Yes
		Bilateral PoCG/precuneus/SPL/PreCG/IPL/MFG/angular/SOG/cuneus	12 653	T₍₃₈₎=5.5	−16	−84	50	Yes
		Right MFG/SFG/PreCG	1273	T₍₃₈₎=5.2	32	14	66	Yes
		Right SFG/SMA/MeFG	659	T₍₃₈₎=4.3	6	38	62	No
	Reappraisal	Left insula	769	T₍₃₀₎=−5.1	−32	−2	22	No

Association between CBF and PSWQ adjusted for HDRS	Worry	Right parahippocampus/amygdala/hippocampus	620	T₍₃₈₎=3.9	18	−2	−18	No
		Right SFG/MeFG	545	T₍₃₈₎=3.7	22	62	−8	Yes
		Left SPL/PoCG	658	T₍₃₈₎=3.5	26	−46	62	Yes
	Reappraisal	Not significant

Abbreviations: BA, Brodmann area; CBF, cerebral blood flow; dACC, dorsal anterior cingulate; GAD, generalized anxiety disorder; HC, healthy controls; HDRS, Hamilton depression rating scale; IFG, inferior frontal; IOG, inferior occipital; IPL, inferior parietal; MCC, middle cingulate; MeFG, medial frontal; MFG, middle frontal; MOG, middle occipital; mPFC, medial prefrontal cortex; MTG, middle temporal; PoCG, postcentral gyrus; PreCG, pre, central gyrus; SFG, superior frontal; SMA, supplemental motor; SOG, superior occipital; SPL, superior parietal; STG, superior temporal.

Each voxel-wise analysis and the significant regions with cluster sizes, max T/F-statistics (with respective degrees of freedom) and x, y, z-coordinates in MNI space. ‘Not significant’ indicates that the results did not pass multiple comparisons correction. The final column indicates whether the cluster passed a non-parametric multiple comparisons correction (SnPM).

Not significant. See Supplementary Figure 1 for analysis of effect sizes.