Table 2. Summary of statistically significant (FDR P<0.05) results from discovery phase.
| Gene symbol | Gene name | Chr | No. of SNPs highlighted | Phenotypes showing association |
SNPs with lowest P-value |
|
|---|---|---|---|---|---|---|
| rs number | P-value | |||||
| APH1A | Aph-1 homolog A | 1 | 2 | Smoking Initiation | rs183423866 | 1.8E−09 |
| PSEN2 | Presenilin 2 | 1 | 1 | Smoking Initiation | rs10916053 | 2.1E−04 |
| ERBB4 | Erb-B2 Receptor Tyrosine Kinase 4 | 2 | 27 | Smoking Initiation | rs13413099 | 4.0E−27 |
| Nicotine Depdendence | rs13385826 | 1.7E−07 | ||||
| Nicotine Withdrawal | rs13006797 | 2.1E−06 | ||||
| NRG1 | Neuregulin 1 | 8 | 24 | Smoking Initiation | rs4329235 | 9.3E−13 |
| NRG3 | Neuregulin3 | 10 | 9 | Smoking Initiation | rs11528179 | 2.9E−07 |
| Nicotine Withdrawal | rs11192578 | 1.2E−06 | ||||
| BACE1 | Beta-secretase 1 | 11 | 2 | Smoking Initiation | rs191109295 | 4.0E−06 |
| PSENEN | Presenilin enhancer | 19 | 1 | Smoking Initiation | rs807483 | 1.7E−04 |
Abbreviations: FDR, false discovery rate; ND, nicotine dependence; NSP, neuregulin signaling pathway; NW, nicotine withdrawal; SI, smoking initiation; SNP, single nucleotide polymorphism. Altogether, 66 SNPs were highlighted in seven of the ten NSP genes with SI, DSM-IV ND diagnosis and DSM-IV NW symptom count phenotypes. For each gene, SNP with the lowest P-values are presented. Complete results for 66 SNPs are presented in Supplementary Table 3.