Table 2. Comparison of erythrocyte membrane phosphatidylethanolamine lipid levels at baseline in patients with mood disorder, psychosis, anxity disorder or other psychiatric disorders after 7 years.
Mood vs no mood (n=26 vs n=43) |
Psychosis vs no psychosis (n=20 vs n=49) |
Anxiety vs no anxiety (n=19 vs n=50) |
Other vs no other (n=11 vs n=58) |
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Effect size (Cohen’sd) | P-value | Effect size (Cohen’sd) | P-value | Effect size (Cohen’sd) | P-value | Effect size (Cohen’sd) | P-value | |
LC ω -6 Fatty Acids | ||||||||
Linolenic acid (18:2n-6)a | −0.553 | 0.035 | 0.139 | 0.543 | 0.003 | 0.990 | −0.178 | 0.610 |
γ-Linolenic acid (18:3n-6) | 0.582 | 0.023 | −0.172 | 0.509 | 0.260 | 0.346 | 0.161 | 0.603 |
Dihomo-γ-linolenic acid (20:3n-6) | 0.299 | 0.229 | −0.114 | 0.683 | −0.127 | 0.645 | 0.264 | 0.458 |
Arachidonic acid (20:4n-6) | −0.191 | 0.447 | −0.316 | 0.213 | −0.211 | 0.410 | −0.275 | 0.371 |
Docosadienoic acid (22:2n-6) | 0.612 | 0.017 | −0.213 | 0.420 | 0.015 | 0.954 | −0.188 | 0.579 |
Adrenic acid (22:4n-6) | 0.243 | 0.327 | −0.242 | 0.344 | −0.148 | 0.592 | −0.014 | 0.965 |
LC ω -3 Fatty Acids | ||||||||
a-Linolenic acid (18:3n-3)a | −0.073 | 0.775 | 0.106 | 0.696 | −0.307 | 0.272 | 0.157 | 0.650 |
Eicosapentaenoic acid (20:5n-3)a | −0.729 | 0.003 | −0.134 | 0.612 | −0.467 | 0.077 | −0.233 | 0.497 |
Docosapentaenoic acid (22:5n-3) | −0.443 | 0.076 | 0.018 | 0.942 | −0.134 | 0.616 | −0.058 | 0.877 |
Docosahexaenoic acid (22:6n-3) | −0.618 | 0.010 | −0.092 | 0.749 | −0.486 | 0.090 | −0.625 | 0.087 |
Sums and Ratios | ||||||||
Sum of LC ω-6 fatty acidsb | −0.199 | 0.413 | −0.237 | 0.349 | −0.149 | 0.565 | −0.235 | 0.541 |
Sum of LC ω-3 fatty acidsb | −0.699 | 0.004 | −0.069 | 0.911 | −0.436 | 0.111 | −0.472 | 0.197 |
LC ω -6 to LC ω-3 fatty acids ratio | 0.610 | 0.012 | 0.008 | 0.975 | 0.278 | 0.335 | 0.283 | 0.435 |
Log transformed.
Sum comprises long-chain fatty acids ⩾20 carbon atoms.