Table 3. Odds ratios for mood disorder at 7 years follow-up for erythrocyte membrane phosphatidylethanolamine lipid levels at baseline in patients with mood disorders.

	Unadjusted		Model 1a		Model 2b
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
ω -6 Fatty Acids
Linolenic acid (18:2n-6)	0.324 (0.111–0.942)	0.038	0.254 (0.078–0.827)	0.023	0.287 (0.086–0.950)	0.041
r-Linolenic acid (18:3n-6)	1.835 (1.069–3.150)	0.028	1.881 (1.083–3.268)	0.025	1.800 (1.028–3.150)	0.040
Docosadienoic acid (22:2n-6)	1.856 (1.095–3.145)	0.022	1.810 (1.051–3.117)	0.033	1.776 (1.029–3.065)	0.039
ω-3 Fatty Acids
Eicosapentaenoic acid (20:5n-3)	0.383 (0.185–0.793)	0.010	0.372 (0.178–0.781)	0.009	0.390 (0.172–0.883)	0.024
Docosahexaenoic acid (22:6n-3)	0.506 (0.276–0.928)	0.028	0.517 (0.279–0.960)	0.037	0.488 (0.261–0.913)	0.025
Sums and ratios
Sum of ω-3 fatty acids	0.453 (0.236–0.869)	0.017	0.446 (0.228–0.874)	0.019	0.436 (0.200–0.950)	0.037
ω -6 to ω-3 fatty acids ratio	1.894 (1.075–3.338)	0.027	1.843 (1.035–3.284)	0.038	1.815 (1.024–3.289)	0.041

Abbreviations: PUFAs, polyunsaturated fatty acids.

^aAdjusted for age, sex and smoking at baseline.

^bAdjusted for age, sex, smoking, MADRS score and ω -3 PUFA/placebo group status at baseline.