Table 2. Comparison of ¹¹C-(R)-PK11195 BP_ND across the five study groups.

	Young HC		UHR		Recent-onset SCZ		Older HC		Chronic SCZ		UHR vs young HC			Recent-onset vs young HC			Chronic vs older HC
	M	s.d.	M	s.d.	M	s.d.	M	s.d.	M	s.d.	t	P	d	t	P	d	t	P	d
Dorsal frontal	0.90	0.04	0.9	0.02	0.9	0.05	0.89	0.04	0.91	0.04	0.38	0.71	0.08	0.28	0.78	0.05	−1.34	0.19	−0.26
Orbital frontal	0.93	0.05	0.91	0.04	0.92	0.06	0.93	0.05	0.95	0.05	1.05	0.30	0.21	0.63	0.53	0.11	−1.16	0.26	−0.22
Medial temporal	0.80	0.04	0.80	0.03	0.80	0.04	0.8	0.04	0.82	0.02	−0.23	0.82	−0.05	0.24	0.81	0.04	−1.32	0.20	−0.25
Thalamus	0.93	0.06	0.92	0.05	0.91	0.04	0.98	0.04	0.96	0.06	0.19	0.85	0.04	1.01	0.32	0.18	0.88	0.39	0.17
Insular cortex	0.89	0.04	0.88	0.03	0.86	0.05	0.89	0.03	0.89	0.03	0.74	0.47	0.15	1.91	0.06	0.33	0.48	0.64	0.09
ACC	0.86	0.03	0.84	0.04	0.84	0.04	0.88	0.05	0.87	0.05	1.73	0.10	0.35	1.82	0.08	0.32	0.50	0.62	0.10

Abbreviations: ACC, anterior cingulate cortex; BP_ND, binding potential; d, effect size (Cohen’s d) HC, healthy control; M, mean; P, uncorrected P-value; SCZ, schizophrenia; s.d., standard deviation; t, t statistic; UHR, ultra-high-risk. Equal variances not assumed.