FIGURE 4.

Effect sizes of studies that assessed primary risk of congenital abnormalities according to rs1801198 that were determined with the use of a CC compared with CG/GG genetic model (A) or GG compared with CG/CC genetic model (B). The calculated summary effects are denoted by the solid diamonds at the bottom of the forest plots, the widths of which represent the 95% CIs. For each study, the gray box and the horizontal line denote the central value of the effect size and its 95% CI, respectively. CL, cleft lip; DL, DerSimonian and Laird procedure; DS, Down syndrome; FI, female infertility; NTD, neural tube defects; RE, random-effects model; SA, spontaneous abortion.