Fig.1.

T1-weighted MRI, FDG-PET and PiB-PET images of four representative participants. A 64-year-old female AD patient with positive Aβ deposition on PiB-PET and “AD” type of hypometabolism on FDG-PET (A); a 76-year-old female MCI subject with positive Aβ deposition on PiB-PET and “AD” type of hypometabolism on FDG-PET (B); a 78-year-old female AD patient with negative PiB and “FTD” type of hypometabolism (C); and a 71-year-old male AD patient with negative PiB and non-specific hypometabolism on FDG-PET (D). FDG, fluorodeoxyglucose; PiB, Pittsburgh compound B; PET, positron emission tomography; AD, Alzheimer’s disease; MCI, mild cognitive impairment; FTD, frontotemporal dementia.