Table 2.

Change from Baseline in FVC [mL] by treatment group and between-treatment group difference by analysis method

Analysis method	Idebenone (N = 31)		Placebo (N = 33)		Group Difference
	Estimated	p-value	Estimated	p-value	Estimated	p-value
	Change		Change		Difference
	(95% CI)		(95% CI)		(95% CI)
MMRM at week 13	13 (–51, 78)	0.679	–80 (–143, –17)	0.014	93 (3, 183)	0.043
MMRM at week 26	10 (–62, 81)	0.787	–147 (–217, –77)	<0.001	157 (56, 257)	0.003
MMRM at week 39	14 (–68, 95)	0.739	–148 (–223, –72)	<0.001	161 (50, 272)	0.005
MMRM at week 52	–41 (–139, 56)	0.402	–175 (–267, –83)	<0.001	134 (–0, 268)	0.050
MMRM for weeks 13–52	–1 (–64, 61)	0.972	–137 (–197, –77)	<0.001	136 (50, 223)	0.003
Slope analysis for weeks 13–52	–8 (–66, 49)	0.770	–131 (–187, –75)	<0.001	122 (48, 197)	0.002

Estimated changes and differences are in mL. MMRM: mixed model for repeated measurements; slope analysis: random coefficient regression model.