Table 3.

Change from Baseline in FVC% p by treatment group and between-treatment group difference by analysis method

Analysis method	Idebenone (N = 31)		Placebo (N = 33)		Group Difference
	Estimated	p-value	Estimated	p-value	Estimated	p-value
	Change		Change		Difference
	(95% CI)		(95% CI)		(95% CI)
MMRM at week 13	–0.48 (–2.44, 1.48)	0.626	–3.75 (–5.67, –1.83)	<0.001	3.27 (0.51, 6.03)	0.021
MMRM at week 26	–1.69 (–3.77, 0.38)	0.108	–6.41 (–8,44, –4.38)	<0.001	4.72 (1.80, 7.63)	0.002
MMRM at week 39	–2.86 (–5.86, 0.13)	0.061	–7.84 (–10.64, –5.03)	<0.001	4.97 (0.86, 9.09)	0.019
MMRM at week 52	–5.67 (–8.36, –2.99)	<0.001	–8.95 (–11.47, –6.42)	<0.001	3.27 (–0.43, 6.97)	0.082
MMRM for weeks 13–52	–2.68 (–4.68, –0.68)	0.009	–6.74 (–8.65, –4.82)	<0.001	4.06 (1.28, 6.84)	0.005
Slope analysis for weeks 13–52	–2.55 (–4.38, –0.72)	0.007	–6.69 (–8.47, –4.90)	<0.001	4.13 (1.73, 6.54)	<0.001

MMRM: mixed model for repeated measurements; slope analysis: random coefficient regression model.