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. Author manuscript; available in PMC: 2018 Aug 9.
Published in final edited form as: Chem Rev. 2017 Jun 27;117(15):10043–10120. doi: 10.1021/acs.chemrev.7b00042

Figure 8.

Figure 8

Formation of Phenyl Radicals During the Reaction of Mitochondria-Targeted Phenylboronates (MitoPhB(OH)2) with ONOO−. (A) Chemical scheme showing the two pathways of the reaction of MitoPhB(OH)2 isomers with ONOO−: major nonradical pathway (blue) and minor, radical-mediated pathway (red). (B) EPR spectra detected after reacting three MitoPhB(OH)2 isomers with ONOO− in the presence of the MNP spin trap. (Adapted with permission from Ref.295. This research was originally published in The Journal of Biological Chemistry. Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, Ayhan MM, Podsiadly R, Sikora A, Lambeth JD. Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. The Journal of Biological Chemistry. 2016; 291:7029–7044. © the American Society for Biochemistry and Molecular Biology.)