Fig.2.
Concordance and discordance between amyloid markers. CSF Aβ1–42 and [18F]AV45 PET (SUVRCB, SUVRWM) were compared for three different Aβ1–42 cutoffs, established in a neuropathological confirmed cohort [53] (A), derived by a ROC-based analysis on this dataset for SUVRCB (B), and SUVRWM (C). Concordance increased by applying new Aβ1–42 cutoffs. The concordance changed from κ= 0.379 and κ= 0.301 (respectively, SUVRCB and SUVRWM) to κ= 0.774 and κ= 0.647 (B), and κ= 0.729 and κ= 0.853 (C). Aβ, amyloid-β; [18F]AV45, [18F]Florbetapir; CB, cerebellar grey matter; CSF, cerebrospinal fluid; ROC, Receiver operating characteristics; SUVR, standardized uptake value ratio; WM, whole subcortical white matter.