Fig. 7.

SC numbers and proliferation are increased in Sox2-overexpressing nerves. (A-F) Ki67 labelling of sciatic nerves taken from P7 control (A-C) and Sox2^HomoOE (D-F) mice. Scale bar: 40 µm. Insets in D-F show higher magnification of Ki67/GFP-positive SCs. (G,H) There is an increase in the number of SC nuclei in P7 (G) and P60 (H) Sox2^HomoOE sciatic nerves compared with controls. Numbers given are total nuclei per sciatic nerve transverse section. (I,J) There is a significant increase in the number of GFP/Ki67-positive nuclei in P7 (I) and P60 (J) Sox2^HomoOE sciatic nerves. (G-J) Two-sided two-sample Student's t-test; data from n=3 mice of each genotype at each time point; *P<0.05, **P<0.01.