Fig. 3.

Models for differentiation-induced centrosome inactivation. (A) Both transcriptional downregulation of centrosomal components and decreased signaling through cell-cycle regulators accompany microtubule reorganization. (B) Specific loss of microtubule anchoring can be the first step in centrosome inactivation; this can be mediated through increased microtubule severing or delocalization/degradation of specific anchoring factors. (C) Centrosome inactivation can also be caused by a general dispersal of pericentriolar material. Note that the mechanisms illustrated in B and C are not mutually exclusive.