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Potential models of non-centrosomal MTOC activation. (A) Centrosomal proteins can be relocalized to a novel cellular site to re-specify that site for microtubule nucleation and/or anchoring. (B) A distinct set of non-centrosomal proteins can be utilized to generate non-centrosomal MTOCs. (C) Non-centrosomal arrays can be generated through microtubule severing and subsequent reorganization independently of new nucleation. These models are not mutually exclusive.
