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. 2017 Sep 1;10(9):1117–1128. doi: 10.1242/dmm.029801

Fig. 8.

Fig. 8.

Activation of L1-mediated intracellular signaling cascades in cultured mouse cerebellar granule cells treated with honokiol. (A-E) L1 levels (A), phosphorylation levels of Akt1 (B) and Erk1/2 (C), protein levels of mTOR (D), and the ratio of Bcl-2/Bax levels (E) in cultured mouse cerebellar granule cells treated with honokiol (HNK) at concentrations of 0, 50, 100 and 200 nM. *P<0.05, **P<0.01, ***P<0.001 versus the vehicle control; one-way ANOVA with Tukey's post hoc test; three independent experiments. Blots in B-E are from the same gel and therefore have the same β-actin loading controls.