. 2017 Jun 14;51(3):307–316. doi: 10.1515/raon-2017-0022

Table 1.

Histological findings in the salivary glands of the rats. Mean values of salivary gland damage parameters are given. *Details of groups are given below the table

Site of damage	Investigated parameters	Control			Group 1			Group 2			Group 3			Group 4			Group 5			Group 6

		1^st m	6^th m	p	1^st m	6^th m	p	1^st m	6^th m	p	1^st m	6^th m	p	1^st m	6^th m	p	1^st m	6^th m	p	1^st m	6^th m	p
	Edema	3.67	5.5	ns	6	7.17	ns	5.67	7.67	*0.05*	5	5.5	ns	4.33	7	*0.02*	4.33	4.83	ns	5.67	3	*0.02*
Acinar epithelial cell damage	Vacuolization	4.33	3.5	ns	6.67	6.33	ns	5	7	*0.04*	4.67	4.17	ns	4	5.33	ns	5	3.67	ns	5.33	2	*0.02*
Acinar epithelial cell damage	Peri acinar inflammation	0	0	ns	0.67	0.17	ns	1.33	0.17	ns	0.67	0.17	ns	0	0.17	ns	0	0.17	ns	2	0	*0.02*
	Necrosis	0.67	2.33	ns	0	1.33	*0.04*	2	0.5	ns	1.67	1	ns	0	1	ns	0.33	0	ns	0.67	0.17	ns
Ductal system damage	Ectasia	3	3.33	ns	6.33	5.83	ns	4.33	6	ns	3.67	2.5	ns	2.67	4.67	*0.01*	3.67	3.5	ns	3.33	0.83	*0.04*
	Periductal fibrosis	0	0	ns	1	3.33	*0.02*	2.33	3.33	ns	1	0.33	ns	0	2.33	*0.02*	0	1.33	*0.01*	0	0.67	ns
Interstitial space damage	Periduktal sclerosis	0	0.17	ns	0	2.17	*0.02*	1.33	1.83	ns	1	0	*0.03*	0	0.33	ns	0	0.67	ns	0	0	ns
	Periductal mucus leakage	1	0.5	ns	1	1	ns	0.67	1.33	ns	1.33	1	ns	0.33	0.83	ns	0.33	0.33	ns	3	0.5	*0.02*
Vascular system damage	Sclerosis	0	0.17	ns	1	4.5	*0.01*	1.67	3.5	ns	1.33	0.5	ns	0.67	1.17	ns	0	1.17	*0.01*	1.67	0.5	ns
	Total	12.67	15.5	ns	22.67	31.83	*0.02*	24.33	31.33	ns	20.34	15.17	0.05	12	22.83	*0.02*	13.66	15.67	ns	21.67	7.67	*0.02*

Control = healthy subjects; Group 1= radioiodine; Group 2 = adipose tissue-derived mesenchymal stem cells; Group 3 = amifostine; Group 4 = radioiodine plus amifostine; Group 5 = radioiodine plus adipose tissue-derived mesenchymal stem cells concomitant; Group 6 = radioiodine plus adipose tissue-derived mesenchymal stem cells after 48 h; ns = not significant.