Table 1.
Affinities for binding of purified evasins to human CC chemokines
Affinities are reported as pKd values (−log10 of the Kd; in m) ±S.E. The corresponding Kd values (in nm) are in parentheses. The affinity of RSA evasin-4 for MCP-3 (not shown in the table) was pKd = 9.21 ± 0.2 (Kd = 0.62 nm).
| Evasin | Chemokine |
||||
|---|---|---|---|---|---|
| Eotaxin-1 | Eotaxin-2 | Eotaxin-3 | MCP-1 | MCP-2 | |
| RSA evasin-4 | 9.25 ± 0.20 (0.57) | 8.15 ± 0.10 (7.1) | 8.00 ± 0.10 (10) | 7.71 ± 0.09 (20) | 7.68 ± 0.07 (21) |
| RPU-01 | 7.88 ± 0.08 (13) | 6.81 ± 0.05 (150) | 7.44 ± 0.04 (36) | 7.39 ± 0.07 (40) | 7.78 ± 0.06 (17) |
| ACA-01 | 7.94 ± 0.07 (12) | 6.05 ± 0.07 (890) | 6.16 ± 0.05 (690) | 6.45 ± 0.04 (360) | 8.09 ± 0.10 (8.1) |
| IRI-01 | 6.76 ± 0.06 (170) | a | 6.46 ± 0.04 (350) | 5.95 ± 0.05 (1100) | 5.97 ± 0.04 (1100) |
| IHO-01 | 6.90 ± 0.06 (130) | 6.48 ± 0.05 (330) | 7.08 ± 0.03 (83) | 6.04 ± 0.08 (920) | 6.10 ± 0.06 (800) |
a Kd >1 mm (pKd + S.E. <6).