Table 2.
Affinities for binding of nine evasin candidates to six human CC chemokines
Affinities are reported as pKd values (−log10 of the Kd; in m) ±S.E. The corresponding Kd values (in nm) are in parentheses.
| Evasin | Chemokine |
|||||
|---|---|---|---|---|---|---|
| Eotaxin-1 | Eotaxin-2 | Eotaxin-3 | MCP-1 | MCP-2 | MCP-3 | |
| RPU-01 | 7.26 ± 0.09 (55) | 7.06 ± 0.09 (86) | 7.28 ± 0.10 (53) | 6.74 ± 0.08 (180) | 7.11 ± 0.10 (77) | 7.70 ± 0.10 (20) |
| RPU-02 | 7.33 ± 0.06 (74) | 6.88 ± 0.09 (130) | 7.63 ± 0.09 (23) | 6.33 ± 0.04 (470) | 6.27 ± 0.10 (540) | 7.09 ± 0.06 (81) |
| AAM-01 | 7.66 ± 0.03 (22) | 6.88 ± 0.04 (130) | 7.73 ± 0.05 (19) | 6.06 ± 0.10 (870) | 5.94 ± 0.09 (1100) | 6.99 ± 0.04 (100) |
| AAM-02 | 7.72 ± 0.09 (19) | 6.87 ± 0.09 (130) | 7.77 ± 0.07 (170) | 5.99 ± 0.10 (1000) | a | 6.75 ± 0.05 (180) |
| ACA-01 | 7.93 ± 0.10 (12) | 7.16 ± 0.09 (70) | 7.26 ± 0.10 (55) | 6.79 ± 0.07 (160) | 8.24 ± 0.10 (5.8) | 7.76 ± 0.05 (17) |
| ACA-02 | 6.73 ± 0.03 (180) | 5.94 ± 0.10 (1100) | 6.65 ± 0.04 (220) | a | a | a |
| AMA-01 | 7.60 ± 0.05 (25) | 6.94 ± 0.05 (120) | 7.66 ± 0.05 (22) | 6.38 ± 0.10 (420) | 6.33 ± 0.06 (470) | 6.97 ± 0.03 (110) |
| ATR-02 | 7.41 ± 0.09 (39) | 6.87 ± 0.09 (140) | 7.35 ± 0.07 (44) | 5.99 ± 0.20 (1000) | 6.22 ± 0.08 (610) | 7.01 ± 0.07 (98) |
| IRI-01 | 7.28 ± 0.10 (53) | 6.95 ± 0.10 (110) | 6.80 ± 0.10 (160) | 6.70 ± 0.06 (200) | 6.85 ± 0.09 (140) | 7.39 ± 0.09 (41) |
a Kd >1 mm (pKd + S.E. <6) or binding not detected.