Table 3.
Inhibition constants for inhibition of chemokine activity by purified evasins
Inhibition constants are reported as pIC50 values (−log10 of the IC50; in m) ±S.E. The corresponding IC50 values (in nm) are in parentheses.
MCP-1 | MCP-2 | Eotaxin-1 | Eotaxin-2 | |
---|---|---|---|---|
RSA evasin-4 | a | 7.00 ± 0.2 (100) | 6.65 ± 0.2 (220) | 5.99 ± 0.1 (1000) |
RPU-01 | 7.47 ± 0.3 (34) | 6.68 ± 0.1 (210) | 6.03 ± 0.3 (940) | a |
ACA-01 | a | 7.07 ± 0.1 (84) | 6.39 ± 0.2 (400) | a |
IHO-01 | b | b | 6.20 ± 0.2 (630) | 5.95 ± 0.2 (1100) |
a IC50 >1 μm (pIC50 + S.E. <6) or no inhibition detected.
b Not determined.