Figure 6.

A model for ATP hydrolysis by periplasmic solute-binding protein–dependent ABC transporter. The model shows the following steps: (i) resting state before docking of AlgM1M2SS and AlgQ2; (ii) pretranslocation state at the moment of interaction between AlgM1M2SS in the inward-facing conformation and ligand-bound AlgQ2 in the closed conformation; (iii) docking-dependent ATP binding and hydrolysis; and (iv) substrate import or return to resting state in the case of non-transport substrate.