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. 2017 Aug 9;292(38):15916–15926. doi: 10.1074/jbc.M117.796771

Figure 5.

Figure 5.

The miR-125b/SUV39H1 axis regulates development of NT embryos. A and B, the miR-125b/SUV39H1 axis regulates NT-blastocyst formation and hatching. Shown are control embryos and the embryos injected with either a miR-125b inhibitor and si-SUV39H1 (A) or a miR-125b mimic and SUV39H1 (B). The percentages of embryos that reached the indicated stages are shown (*, p < 0.05). Error bars indicate S.D. C and D, representative images of control SCNT embryos and those injected with either a miR-125b inhibitor and si-SUV39H1 (C) or a miR-125b mimic and SUV39H1 (D) at 8 days post-activation. Scale bar = 150 μm. E and F, plots show the total: ICM and TE cell numbers of control; miR-125b inhibitor (E) and miR-125b mimic-injected somatic cell NT-embryos (F). Different characters a, b (total), a′, b′ (TE), or a″, b″ (ICM) above plots indicate significant differences (p < 0.05).