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. 2017 Sep 15;130(18):3094–3107. doi: 10.1242/jcs.200329

Fig. 5.

Fig. 5.

Sharpin promotes lamellipodium formation through interaction with the Arp2/3 complex. (A) Sharpin-silenced NCI-H460 cells or (B) Sharpin KO2 NCI-H460 cells overexpressing the indicated proteins were stained for cortactin. Graphs depict the number of GFP-positive cells with cortactin-positive lamellipodia, relative to GFP–Sharpin WT, for (A) Sharpin-silenced (n=4 experiments, >30 cells per condition per experiment) and (B) Sharpin-knockout cells (n=3 or 4 experiments, 19–56 cells per condition per experiment). All numerical data are mean±s.e.m. *P<0.05, **P<0.01. Scale bars: 10 μm.