Figure 2.

GRMD dogs showed significant variation in phenotype. A) Normal dog (Winthrop) at 6 months of age. B) Mildly affected GRMD dog (Lunes) at 6 months of age. Note the mild muscle atrophy of the pelvic limbs (black arrows) and mild hyperextension of the carpal joints. C) Severely affected GRMD dog (Kermit) at 6 months. Note the prominent joint angle changes and postural deficits, particularly at the carpal, tibiotarsal, stifle, and hip joints, which were due to severe muscle weakness/wasting and joint contractures.